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Publications

To see all publications that our lab has contributed to including collaborative projects, please visit PubMed:                                          

Here are our key manuscripts:

2021

2023

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  1. Divergent Total Synthesis of Fornicin A, Fornicin D, and Ganodercin D, Meroterpenoids from Ganoderma Mushrooms. Bunt, D.,  El Aidy S,, Minnaard, AJ. EurJOC (2023). ahead of print

  2. Potential binding modes of the gut bacterial metabolite, 5-hydroxyindole, to the intestinal L-type calcium channels and its impact on the microbiota in rats. Waclawiková B, Cesar Telles de Souza P, Schwalbe M, Neochoritis CG, Hoornenborg W, Nelemans SA, Marrink SJ, El Aidy S. Gut Microbes (2023);15(1):2154544. doi: 10.1080/19490976.2022.2154544

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  1. Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapy. Krieg C, Weber LM, Fosso B, Marzano M, Hardiman G, Olcina MM, Domingo E, El Aidy S, Mallah K, Robinson MD, Guglietta S. J Immunother Cancer (2022);10(9):e004717. doi: 10.1136/jitc-2022-004717.

  2. Mitochondrial interaction of fibrosis-protective 5-methoxy tryptophan enhances collagen uptake by macrophages. Maassen S, Warner H, Ioannidis M, Jansma J, Markus H, El Aidy S, Chiara MD, Chiara JL, Maierhofer L, Weavers H, van den Bogaart G. Free Radic Biol Med. (2022);188:287-297. doi: 10.1016/j.freeradbiomed.2022.06.235. 

  3. Jansma, J.*, van Essen, R.*, Haarman, B.C.M.,  Chatziioannou, AC., Borkent,J.,  Ioannou, M., van Hemert, S.,  Sommer, IEC,  El Aidy, S. Metabolic phenotyping reveals a potential link between elevated faecal amino acids, diet and symptom severity in individuals with severe mental illness.  Psychiatr Res. (2022 );151:507-515. doi: 10.1016/j.jpsychires.2022.05.011.

  4. Gut microbiota transplantation drives the adoptive transfer of colonic genotype-phenotype characteristics between mice lacking catestatin and their wild type counterparts. González-Dávila P, Schwalbe M, Danewalia A, Wardenaar R, Dalile B, Verbeke K, Mahata SK, El Aidy S.Gut Microbes. (2022);14(1):2081476. doi: 10.1080/19490976.2022.2081476.

  5. Catestatin selects for colonization of antimicrobial-resistant gut bacterial communities. González-Dávila P, Schwalbe M, Danewalia A, Dalile B, Verbeke K, Mahata SK, El Aidy S.ISME J (2022);16(8):1873-1882. doi: 10.1038/s41396-022-01240-9. 

  6. van Kessel, S.P., Bullock, A., van Dijk, GJ., El Aidy, S. Parkinson's disease medication alters small intestinal motility and microbiota composition in healthy rats. mSystems (2022) 22;7(1):e0119121.

  7. Waclawiková, B., Codutti, A., Alim, K., El Aidy, S. Gut microbiota-motility interregulation: insights from in vivo, ex vivo and in silico studies. . Gut microbes (2022) 14 (1), 1997296

  8. Waclawiková, B., El Aidy, S. 5-hydroxyindole and analogs thereof as stimulants of gut motility. WO Patent (2022) 2022010352

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2022

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2021

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  1. van Kessel, S.P., Auvinen, P., Scheperjans, F., El Aidy, S. Gut bacterial tyrosine decarboxylase associates with clinical variables in a longitudinal cohort study of Parkinsons disease. NPJ Parkinson's disease (2021) 7 (1), 1-8.

  2. Aresti-Sanz, J., Schwalbe, M., Pereira, R.R., Permentier, H., El Aidy, S. Stability of Methylphenidate under Various pH Conditions in the Presence or Absence of Gut Microbiota. Pharmaceuticals (2021) 14 (8), 733.

  3. Bunt, D.V., Minnaard, A.J., El Aidy, S. Potential Modulatory Microbiome Therapies for Prevention or Treatment of Inflammatory Bowel Diseases. Pharmaceuticals (2021) 14 (6), 506.

  4. Muntjewerff, E.M., Tang, K., Lutter, L, Christoffersson, G., Nicolasen, M.J.T., Gao, H., Katkar, G.D.,  Das, S.,  Beest, M.T., Ying, W., Ghosh, P., El Aidy S., Oldenburg, B., van den Bogaart,G., Mahata, S.K. Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides. Acta Physiol (Oxf). (2021) 30;e13655.

  5. Waclawiková, B., Bullock, A., Schwalbe, M., Aranzamendi, C., Nelemans, S.A., van Dijk, G., El Aidy, S. Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels. PLoS biology. (2021) 19(1) e3001070.

  6. Jansma, J., El Aidy, S. Understanding the host-microbe interactions using metabolic modeling. Microbiome (2021) 9:16

  7. Kiewiet, M. BG., Elderman, M., El Aidy, S., Burgerhof, J. GM., Visser, H., Vaughan, E.E., Faas, M.M,  de Vos, P. Flexibility of Gut Microbiota in Ageing Individuals during Dietary Fiber Long‐chain Inulin Intake. Molecular Nutrition & Food Research. (2021) 64(4), 2000390.

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2020

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  1. Morais, L.H., Golubeva, A.V., Moloney, G.M., Moya-Pérez, A., Ventura-Silva, A.P., Arboleya, S., Bastiaanssen, T.F.S., O'Sullivan, O., Rea, K., Borre, Y., Scott, K.A., Patterson, E., Cherry, P., Stilling, R., Hoban, A.E., El Aidy, S., Sequeira, A.M., Beers, S., Moloney, R.D., Renes, I.B., Wang, S., Knol, J., Ross, R.P., O'Toole, P.W., Cotter, P.D., Stanton, C., Dinan, T.G., Cryan, J.F.Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse. Current Biology. S0960-9822(20)31069-1.

  2. Jansma, J., Brinkman, F., van Hemert, S.,  El Aidy, S. Targeting the endocannabinoid system with microbial interventions to improve gut integrity. Progress in Neuro-Psychopharmacology and Biological Psychiatry. (2020) 110169.

  3. van Kessel, S.P., de Jong, H.R.,  Winkel, S.L.,  van Leeuwen, S.S.,  Nelemans, S.A., Permentier,H., Keshavarzian, A., El Aidy,S. Bacterial deamination of residual levodopa medication for Parkinson's disease elicits inhibitory effect on gut motility. BMC Biol. (2020) 18:137.

  4. Aresti,J.,  Maho,W.,  Rodrigues Pereira,R., Permentier,H.,  El Aidy,S. pH-dependent spontaneous hydrolysis rather than gut bacterial metabolism reduces levels of the ADHD treatment, Methylphenidate. BioRxiv. doi: https://doi.org/10.1101/2020.07.06.189191

  5. Gwilt, K.B., González, P.D., Olliffe, N., Oller, H., Hoffing,R.,  Puzan, M., El Aidy S, Miller, M.G. Actions of trace amines in the brain-gut-microbiome axis via trace amine associated receptor-1 (TAAR1).  Cellular and Molecular Neurobiology. 40 (2), 191-201

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2019

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  1. van Kessel, S. P., El Aidy S. Contributions of Gut Bacteria and Diet to Drug Pharmacokinetics in the Treatment of Parkinson's Disease. Front Neurol. 10:1087. 

  2. van Kessel, S. P., El Aidy S.  Bacterial metabolites mirror altered gut microbiota composition in patients with Parkinson's disease. The Journal of Parkinson's Disease 9(s2):S359-S370.

  3. Torres-Fuentes C, Golubeva AV, Zhdanov AV, Wallace S, Arboleya S, Papkovsky DB, El Aidy S, Ross P, Roy BL, Stanton C, Dinan TG, Cryan JF, Schellekens H.Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling. FASEB J.33(12):13546-13559.

  4. El Aidy, S., Bolsius, Y.G., Raven, F., Havekes, R. (2019). A brief period of sleep deprivation leads to subtle changes in mouse gut microbiota. J Sleep Res. :e12920. 

  5. Aresti J., El Aidy S. Microbiota and gut neuropeptides: a dual action of antimicrobial activity and neuroimmune response. Psychopharmacology, 236(5), 1597-1609.

  6. Aarts E., El Aidy S. (2019). Increasing reproducibility and interpretability of microbiota-gut-brain studies on human neurocognition and intermediary microbial metabolites. Behavioral and Brain Sciences, 42, E61. 

  7. van Kessel, S. P., Frye, A. K., El-Gendy, A. O., Castejon, M., Keshavarzian, A., van Dijk, G., El Aidy, S. Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson's disease. Nature Communications, 10(1), [310].

2018
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  1. Bears, A., Oosting, A., Lohuis, M., Koehorse, M., El Aidy, S., Hugenholtz, F., ... Fransen, F. (2018). Sex differences in lipid metabolism are affected by presence of the gut microbiota. Scientific Reports, 8, [13426]

  2. Waclawiková, B., El Aidy, S. Role of Microbiota and Tryptophan Metabolites in the Remote Effect of Intestinal Inflammation on Brain and Depression. Pharmaceuticals, 11, 3, [63]

2017
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  1. Fransen, F., van Beek, A. A., Borghuis, T., El Aidy, S., Hugenholtz, F., van der Gaast-de Jongh, C., ... de Vos, P. Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice. Frontiers in Immunology, 8, [1385] 

  2. Koopman, M., MIDtrauma Consortium, El Aidy, S.. Depressed gut? The microbiota-diet-inflammation trialogue in depression. Current opinion in psychiatry, 30(5), 369-377 

  3. El Aidy, S., Ramsteijn, A. S., Dini-Andreote, F., van Eijk, R., Houwing, D. J., Salles, J. F., & Olivier, J. D. A. Serotonin transporter genotype modulates the gut microbiota composition in young rats, an effect augmented by early life stress. Frontiers in cellular neuroscience, 11, [222]

  4. Vinke, P. C., El Aidy, S., van Dijk, G. The Role of Supplemental Complex Dietary Carbohydrates and Gut Microbiota in Promoting Cardiometabolic and Immunological Health in Obesity: Lessons from Healthy Non-Obese Individuals. Frontiers in nutrition, 4, [34]

  5. Fransen, F., van Beek, A. A., Borghuis, T., Meijer, B., Hugenholtz, F., van der Gaast-de Jongh, C., ...El Aidy, S.,  de Vos, P. The Impact of Gut Microbiota on Gender-Specific Differences in Immunity. Frontiers in Immunology, 8, [754]

  6. Fransen, F., Sahasrabudhe, N. M., Elderman, M., Bosveld, M., El Aidy, S., Hugenholtz, F., ... de Vos, P. . β2→ 1-fructans modulate the immune system in vivo by direct interaction with the mucosa in a microbiota-independent fashion. Frontiers in Immunology, 8, [154]

2016
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  1. Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., ... Dinan, T. G. Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. Journal of Psychiatric Research, 82, 109-118

  2. Sarker, S. A., Sultana, S., Reuteler, G., Moine, D., Descombes, P., Charton, F., ... El Aidy, S., Brüssow, H. Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh. EBioMedicine, 124-137

  3. El Aidy, S., Stilling, R., Dinan, T. G., & Cryan, J. F. Microbiome to Brain: Unravelling the Multidirectional Axes of Communication. In M. Lyte (Ed.), Microbial Endocrinology: Interkingdom Signalling in Infectious Diseases and Health (2 ed., Vol. 874, pp. 301-336). (Advances in Experimental Medicine and Biology; Vol. 874). Springer International Publishing AG

  4. El Aidy, S. De invloed op ons brein. In M. Kleerebezem, W. Hoekstra, & A. van de Graaf (Eds.), Ons microbioom: Wat betekenen bacteriën voor onze gezondheid? (4 ed., Vol. 35, pp. 54-57). (Cahier Biowetenschappen en Maatschappij). Zutphen: Stichting Biowetenschappen en Maatschappij.

2015
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  1. El Aidy, S., Pusceddu, M. M., Crispie, F., O'Sullivan, O., Cotter, P., Stanton, C., ... Dinan, T. G. N-3 Polyunsaturated Fatty Acids (PUFAs) Reverse the Impact of Early-Life Stress on the Gut Microbiota. PLoS ONE, 10(10), [e0142228]

  2. Fransen, F., Zagato, E., Mazzini, E., Fosso, B., Manzari, C., El Aidy, S., ... Rescigno, M. BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity. Immunity, 43(3), 527-40

  3. Menckeberg, C. L., Hol, J., Simons-Oosterhuis, Y., Raatgeep, H. R. C., de Ruiter, L. F., Lindenbergh-Kortleve, D. J., ..El Aidy, S.,..., Samsom, J. N. Human buccal epithelium acquires microbial hyporesponsiveness at birth, a role for secretory leukocyte protease inhibitor. Gut, 64(6), 884-893

  4. El Aidy, S., van den Bogert, B., & Kleerebezem, M. The small intestine microbiota, nutritional modulation and relevance for health. Current Opinion in Biotechnology, 32, 14-20

  5. El Aidy, S., Dinan, T. G., & Cryan, J. F. Gut Microbiota: The conductor in the Orchestra of immune-neuroendocrine communication. Clinical Therapeutics, 37(5), 954-67

2014
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  1. El Aidy, S., Dinan, T. G., & Cryan, J. F. Immune modulation of the brain-gut-microbe axis. Frontiers in Microbiology, 5, [146]

  2. El Aidy, S., Derrien, M., Aardema, R., Hooiveld, G., Richards, S. E., Dane, A., ... Kleerebezem, M. Transient inflammatory-like state and microbial dysbiosis are pivotal in establishment of mucosal homeostasis during colonisation of germ-free mice. Beneficial microbes, 5(1), 67-77

2013
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  1. El Aidy, S., & Kleerebezem, M. Molecular signatures for the dynamic process of establishing intestinal host-microbial homeostasis: potential for disease diagnostics? Current opinion in gastroenterology, 29(6), 621-627.

  2. El Aidy, S., Merrifield, C. A., Derrien, M., van Baarlen, P., Hooiveld, G., Levenez, F., ... Kleerebezem, M. The gut microbiota elicits a profound metabolic reorientation in the mouse jejunal mucosa during conventionalisation. Gut, 62(9), 1306-1314.

  3. Van den Abbeele, P., Verstraete, W., El Aidy, S., Geirnaert, A., & Van de Wiele, T. (2013). Prebiotics, faecal transplants and microbial network units to stimulate biodiversity of the human gut microbiome. Microbial Biotechnology, 6(4), 335-340.

  4. El Aidy, S., Derrien, M., Merrifield, C. A., Levenez, F., Doré, J., Boekschoten, M. V., ... Kleerebezem, M. Gut bacteria-host metabolic interplay during conventionalisation of the mouse germfree colon. The ISME journal, 7(4), 743-755

  5. El Aidy, S., Hooiveld, G., Tremaroli, V., Bäckhed, F., & Kleerebezem, M. The gut microbiota and mucosal homeostasis: colonized at birth or at adulthood, does it matter? Gut Microbes, 4(2), 118-124.

  6. El Aidy, S., Van den Abbeele, P., Van de Wiele, T., Louis, P., & Kleerebezem, M. Intestinal colonization: how key microbial players become established in this dynamic process: microbial metabolic activities and the interplay between the host and microbes. BioEssays, 35(10), 913-923.

2012
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  1. El Aidy, S., Kunze, W., Bienenstock, J., & Kleerebezem, M. The microbiota and the gut-brain axis: insights from the temporal and spatial mucosal alterations during colonisation of the germfree mouse intestine. Beneficial microbes, 3(4), 251-259.

  2. El Aidy, S., van Baarlen, P., Derrien, M., Lindenbergh-Kortleve, D. J., Hooiveld, G., Levenez, F., ... Kleerebezem, M. Temporal and spatial interplay of microbiota and intestinal mucosa drive establishment of immune homeostasis in conventionalized mice. Mucosal immunology, 5(5), 567-579.

2011
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  1. Van den Abbeele, P., Gérard, P., Rabot, S., Bruneau, A., El Aidy, S., Derrien, M., ... Possemiers, S. (2011). Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats. Environmental Microbiology, 13(10), 2667-2680.

2010
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  1. Booijink, C. C. G. M., El Aidy, S., Rajilić-Stojanović, M., Heilig, H. G. H. J., Troost, F. J., Smidt, H., ... Zoetendal, E. G. High temporal and inter-individual variation detected in the human ileal microbiota. Environmental Microbiology, 12(12), 3213-3227.

  2. Van den Abbeele, P., Grootaert, C., Marzorati, M., Possemiers, S., Verstraete, W., Gerard, P.,  Rabot, S.., El Aidy, S.,... Van de Wiele, T. Microbial Community Development in a Dynamic Gut Model Is Reproducible, Colon Region Specific, and Selective for Bacteroidetes and Clostridium Cluster IX. Applied and environmental microbiology, 76(15), 5237-5246.

    Contact us

sahar.elaidy@rug.nl
 

+31(0)50 3632201

+31(0)50 3632088 (secretary)

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Host-microbe Interactions group

Groningen Biomolecular Sciences and Biotechnology Institute (GBB)

​University of Groningen
Nijenborg 7, 9747 AG Groningen

The Netherlands

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